Peoples are usually thinking, what is pain? and How does it transmit and control ? Me also had the same feeling once upon a time. This post will give a suitable answer for all of your questions.
Pain and Gate control theory of pain is an attempt to discuss about how pain sensation is transmitted. Pain is defined as the subjective sensation which accompany the activation of nociceptors and which signals the location and strength of actual or potential tissue damaging stimuli.
Various types of pain may range from mild irritation, through burning and prickling sensation to more intense stabbing and throbbing sensation and finally to agonizing and intractable pain which may be intolerable to many subjects.
Nociceptor afferent enters the spinal cord via dorsal root and makes synaptic connections with other neurons located in the dorsal horn of the spinal cord grey matter, which is the site of convergence of many inputs. The main reflexes involving nociceptor reflex are- Withdrawal reflex and Crossed extensor reflex.
Nociceptive efferent enter the spinal cord, terminate on the dorsal horn and make synaptic connections with-
- 1st- Inter neuron serving reflex.
- 2nd- second order neuron (T cell or transmission cell).
These second order neurons cross the mid line of the spinal cord to transmit the information to the higher center via lateral spinothalamic tract on the contra lateral side of the spinal cord. These ascending neurons reach ventrobasal nuclei of the thalamus where they terminate on the 3rd order neurons which convey the information to the cerebral cortex. Also the information is passed to higher centers via multisynaptic spinoreticular tract.
Modulation of pain transmission
At the level of spinal cord
As noted before primary nociceptive afferent terminate at the 2nd order neuron or T cells. The excitability of this pathway can be altered by other inter neurons present in the dorsal horn. The cells of Substantia gelatinosa have an inhibitory influence on the transmission cell by Presynaptic Inhibition of the nociceptive afferent terminals at the point where they synapse with transmission cells.
Substantia Gelatinosa cells are inhibited when the nociceptive afferents are activated, this reduces the presynaptic inhibition and allows nociceptive information to be passed to higher center. Substantia Gelatinosa cells are stimulated by the activation of low threshold large diameter A beta mechanosensitive afferents. This leads to increase in presynaptic inhibition and prevents the transmission of nociceptive information to be passed to higher centers.
Pain modulation at Higher Centers: Gate control theory of pain
If the nociceptive information is allowed through the gate according to gate control theory of pain, then the traffic will continue up the lateral spinothalamic tract of the spinal cord through the thalamus and to the cerebral cortex. As the stimulus passes through brain stem, it may cause an interaction between Periaqueductal grey matter and the raphe nucleus in the mid brain.
These nuclei form part of the Descending pain suppression system and their neurons lead to the excitation of Substantia Gelatinosa cells and thus will cause inhibition of the pain transmission. The endogenous opioids the enkephelins, endorphins and dianorphins are involved in pain modulation at this level. They are thought to be associated to produce analgesia related only to prolonged pain rather than initial fast pain, produced when an injury first occurs. Therefore the inhibitory effect of higher centers influence the pain transmission mediated through C fibres.
So, according to Gate control theory of pain, Gate is open when Substantia Gelatinosa cells are inhibited as the cells allows nociceptive stimulation to be passed on higher center and the Gate is closed when SG cells are excited. Gate control theory of pain argues that human thoughts, beliefs and emotions affect the amount of pain felt from a given physical sensation. The basis of this theory is that both the psychological and physical factors guide the brain’s interpretation of painful sensations and subsequent response.
Modulation of pain by Physical Therapy
At the level of spinal cord: The large diameter mechanosensitive afferents can be stimulated by large number of modalities. They can be stimulated by direct simple mechanical stimulation of receptors in skin, muscles and joints. Techniques used include- massage, joint mobilisation, traction, compression, thermal stimulation, TENS, IFT, electrical stimulation of muscles.
At the level of Higher Centres: The Physio therapeutic agents which cause stimuli to flow along nociceptive fibres can stimulate the higher centers to inhibit to inhibit the pain transmission. Modalities used include- ice, friction, Ultrasonic therapy, UVR, low TENS, thermotherapy.
At the Periferal level:
i) Chemical released by the tissue injury may stimulate the nociceptive nerve ending. Degree of stimulation depends on the amount of chemical present. Therefore removal of these chemicals by the physio therapeutic agents affecting the circulation may help to reduce the level of nociceptive stimulation. Example- HEAT, ICE, CONTRAST BATH.
ii) Nociceptive fibres have a maximum frequency at which they can conduct. C fibres- 15 pulse/sec and A delta fibres- 40 pulse/sec. If higher frequency of stimulation is applied, a physiologic block to conduction might occur. Example- TENS and IFT.
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